I was wondering if there are any particular disadvantages like e.g. massive page splits, severe index fragmentation, etc if I use GUID's on my database as the PK value across a majority of my tables.
asked Aug 09 '11 at 12:17 PM in Default
You should avoid GUID as PK, but as always "IT DEPENDS". If the table is expected to contain hundreds of millions of records, then you need to tune every single column,index, t-sql statement etc. (every byte counts). But if you expect the table to be tiny (or static), feel free to use GUID (with NEWSEQUENTIALID()) in your PK. You can also create a PK as a nonclustered index, but it all depends on your design and what you are expecting to handle.
Tuning is key to high performing databases and testing is key to avoid unpleasant surprises.
answered Aug 09 '11 at 01:09 PM